RapamycinFungusV1, Main, Exploration, bibRecord, 000C69

Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.

Identifieur interne : 000C69 ( Main/Exploration ); précédent : 000C68; suivant : 000C70

Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.

Auteurs : Nicolas Prevot [États-Unis] ; Kalyani Pyaram [États-Unis] ; Evan Bischoff [États-Unis] ; Jyoti Misra Sen [États-Unis] ; Jonathan D. Powell [États-Unis] ; Cheong-Hee Chang [États-Unis]

Source :

Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2015.

RBID : pubmed:25404366

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Carrier Proteins (genetics), Carrier Proteins (immunology), Cell Differentiation (MeSH), Cell Proliferation (MeSH), Cells, Cultured (MeSH), GATA3 Transcription Factor (biosynthesis), Interferon-gamma (biosynthesis), Interleukin-17 (biosynthesis), Interleukin-4 (biosynthesis), Kruppel-Like Transcription Factors (biosynthesis), Mechanistic Target of Rapamycin Complex 1 (MeSH), Mechanistic Target of Rapamycin Complex 2 (MeSH), Mice (MeSH), Mice, Inbred C57BL (MeSH), Mice, Knockout (MeSH), Multiprotein Complexes (genetics), Multiprotein Complexes (immunology), Natural Killer T-Cells (cytology), Natural Killer T-Cells (immunology), Promyelocytic Leukemia Zinc Finger Protein (MeSH), Rapamycin-Insensitive Companion of mTOR Protein (MeSH), Signal Transduction (genetics), Signal Transduction (immunology), TOR Serine-Threonine Kinases (genetics), TOR Serine-Threonine Kinases (immunology).
MESH :
- chemical , biosynthesis : GATA3 Transcription Factor, Interferon-gamma, Interleukin-17, Interleukin-4, Kruppel-Like Transcription Factors.
- chemical , genetics : Carrier Proteins, Multiprotein Complexes, TOR Serine-Threonine Kinases.
- chemical , immunology : Carrier Proteins, Multiprotein Complexes, TOR Serine-Threonine Kinases.
- cytology : Natural Killer T-Cells.
- genetics : Signal Transduction.
- immunology : Natural Killer T-Cells, Signal Transduction.
- Animals, Cell Differentiation, Cell Proliferation, Cells, Cultured, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Inbred C57BL, Mice, Knockout, Promyelocytic Leukemia Zinc Finger Protein, Rapamycin-Insensitive Companion of mTOR Protein.

Abstract

The mammalian target of rapamycin (mTOR) senses and incorporates different environmental cues via the two signaling complexes mTOR complex 1 (mTORC1) and mTORC2. As a result, mTOR controls cell growth and survival, and also shapes different effector functions of the cells including immune cells such as T cells. We demonstrate in this article that invariant NKT (iNKT) cell development is controlled by mTORC2 in a cell-intrinsic manner. In mice deficient in mTORC2 signaling because of the conditional deletion of the Rictor gene, iNKT cell numbers were reduced in the thymus and periphery. This is caused by decreased proliferation of stage 1 iNKT cells and poor development through subsequent stages. Functionally, iNKT cells devoid of mTORC2 signaling showed reduced number of IL-4-expressing cells, which correlated with a decrease in the transcription factor GATA-3-expressing cells. However, promyelocytic leukemia zinc-finger (PLZF), a critical transcription factor for iNKT cell development, is expressed at a similar level in mTORC2-deficient iNKT cells compared with that in the wild type iNKT cells. Furthermore, cellular localization of PLZF was not altered in the absence of mTOR2 signaling. Thus, our study reveals the PLZF-independent mechanisms of the development and function of iNKT cells regulated by mTORC2.

DOI: 10.4049/jimmunol.1401985
PubMed: 25404366
PubMed Central: PMC4315517

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000D59
to stream Main, to step Curation: 000D59

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.</title>
<author><name sortKey="Prevot, Nicolas" sort="Prevot, Nicolas" uniqKey="Prevot N" first="Nicolas" last="Prevot">Nicolas Prevot</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pyaram, Kalyani" sort="Pyaram, Kalyani" uniqKey="Pyaram K" first="Kalyani" last="Pyaram">Kalyani Pyaram</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bischoff, Evan" sort="Bischoff, Evan" uniqKey="Bischoff E" first="Evan" last="Bischoff">Evan Bischoff</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sen, Jyoti Misra" sort="Sen, Jyoti Misra" uniqKey="Sen J" first="Jyoti Misra" last="Sen">Jyoti Misra Sen</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Powell, Jonathan D" sort="Powell, Jonathan D" uniqKey="Powell J" first="Jonathan D" last="Powell">Jonathan D. Powell</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chang, Cheong Hee" sort="Chang, Cheong Hee" uniqKey="Chang C" first="Cheong-Hee" last="Chang">Cheong-Hee Chang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109; heechang@umich.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor</wicri:regionArea>
<wicri:noRegion>Ann Arbor</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25404366</idno>
<idno type="pmid">25404366</idno>
<idno type="doi">10.4049/jimmunol.1401985</idno>
<idno type="pmc">PMC4315517</idno>
<idno type="wicri:Area/Main/Corpus">000D59</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000D59</idno>
<idno type="wicri:Area/Main/Curation">000D59</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000D59</idno>
<idno type="wicri:Area/Main/Exploration">000D59</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.</title>
<author><name sortKey="Prevot, Nicolas" sort="Prevot, Nicolas" uniqKey="Prevot N" first="Nicolas" last="Prevot">Nicolas Prevot</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pyaram, Kalyani" sort="Pyaram, Kalyani" uniqKey="Pyaram K" first="Kalyani" last="Pyaram">Kalyani Pyaram</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bischoff, Evan" sort="Bischoff, Evan" uniqKey="Bischoff E" first="Evan" last="Bischoff">Evan Bischoff</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sen, Jyoti Misra" sort="Sen, Jyoti Misra" uniqKey="Sen J" first="Jyoti Misra" last="Sen">Jyoti Misra Sen</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Powell, Jonathan D" sort="Powell, Jonathan D" uniqKey="Powell J" first="Jonathan D" last="Powell">Jonathan D. Powell</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chang, Cheong Hee" sort="Chang, Cheong Hee" uniqKey="Chang C" first="Cheong-Hee" last="Chang">Cheong-Hee Chang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109; heechang@umich.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor</wicri:regionArea>
<wicri:noRegion>Ann Arbor</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title>
<idno type="eISSN">1550-6606</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Carrier Proteins (genetics)</term>
<term>Carrier Proteins (immunology)</term>
<term>Cell Differentiation (MeSH)</term>
<term>Cell Proliferation (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>GATA3 Transcription Factor (biosynthesis)</term>
<term>Interferon-gamma (biosynthesis)</term>
<term>Interleukin-17 (biosynthesis)</term>
<term>Interleukin-4 (biosynthesis)</term>
<term>Kruppel-Like Transcription Factors (biosynthesis)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Mice, Knockout (MeSH)</term>
<term>Multiprotein Complexes (genetics)</term>
<term>Multiprotein Complexes (immunology)</term>
<term>Natural Killer T-Cells (cytology)</term>
<term>Natural Killer T-Cells (immunology)</term>
<term>Promyelocytic Leukemia Zinc Finger Protein (MeSH)</term>
<term>Rapamycin-Insensitive Companion of mTOR Protein (MeSH)</term>
<term>Signal Transduction (genetics)</term>
<term>Signal Transduction (immunology)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>TOR Serine-Threonine Kinases (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Cellules T tueuses naturelles (cytologie)</term>
<term>Cellules T tueuses naturelles (immunologie)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Compagnon de mTOR insensible à la rapamycine (MeSH)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexe-2 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (génétique)</term>
<term>Complexes multiprotéiques (immunologie)</term>
<term>Différenciation cellulaire (MeSH)</term>
<term>Facteur de transcription GATA-3 (biosynthèse)</term>
<term>Facteurs de transcription Krüppel-like (biosynthèse)</term>
<term>Interféron gamma (biosynthèse)</term>
<term>Interleukine-17 (biosynthèse)</term>
<term>Interleukine-4 (biosynthèse)</term>
<term>Prolifération cellulaire (MeSH)</term>
<term>Protéine à doigts de zinc de la leucémie promyélocytaire (MeSH)</term>
<term>Protéines de transport (génétique)</term>
<term>Protéines de transport (immunologie)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Souris knockout (MeSH)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Sérine-thréonine kinases TOR (immunologie)</term>
<term>Transduction du signal (génétique)</term>
<term>Transduction du signal (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>GATA3 Transcription Factor</term>
<term>Interferon-gamma</term>
<term>Interleukin-17</term>
<term>Interleukin-4</term>
<term>Kruppel-Like Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term>
<term>Multiprotein Complexes</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Carrier Proteins</term>
<term>Multiprotein Complexes</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Facteur de transcription GATA-3</term>
<term>Facteurs de transcription Krüppel-like</term>
<term>Interféron gamma</term>
<term>Interleukine-17</term>
<term>Interleukine-4</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules T tueuses naturelles</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Natural Killer T-Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Protéines de transport</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules T tueuses naturelles</term>
<term>Complexes multiprotéiques</term>
<term>Protéines de transport</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Natural Killer T-Cells</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Differentiation</term>
<term>Cell Proliferation</term>
<term>Cells, Cultured</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Promyelocytic Leukemia Zinc Finger Protein</term>
<term>Rapamycin-Insensitive Companion of mTOR Protein</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Compagnon de mTOR insensible à la rapamycine</term>
<term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Différenciation cellulaire</term>
<term>Prolifération cellulaire</term>
<term>Protéine à doigts de zinc de la leucémie promyélocytaire</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The mammalian target of rapamycin (mTOR) senses and incorporates different environmental cues via the two signaling complexes mTOR complex 1 (mTORC1) and mTORC2. As a result, mTOR controls cell growth and survival, and also shapes different effector functions of the cells including immune cells such as T cells. We demonstrate in this article that invariant NKT (iNKT) cell development is controlled by mTORC2 in a cell-intrinsic manner. In mice deficient in mTORC2 signaling because of the conditional deletion of the Rictor gene, iNKT cell numbers were reduced in the thymus and periphery. This is caused by decreased proliferation of stage 1 iNKT cells and poor development through subsequent stages. Functionally, iNKT cells devoid of mTORC2 signaling showed reduced number of IL-4-expressing cells, which correlated with a decrease in the transcription factor GATA-3-expressing cells. However, promyelocytic leukemia zinc-finger (PLZF), a critical transcription factor for iNKT cell development, is expressed at a similar level in mTORC2-deficient iNKT cells compared with that in the wild type iNKT cells. Furthermore, cellular localization of PLZF was not altered in the absence of mTOR2 signaling. Thus, our study reveals the PLZF-independent mechanisms of the development and function of iNKT cells regulated by mTORC2. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25404366</PMID>
<DateCompleted><Year>2016</Year>
<Month>02</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1550-6606</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>194</Volume>
<Issue>1</Issue>
<PubDate><Year>2015</Year>
<Month>Jan</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Journal of immunology (Baltimore, Md. : 1950)</Title>
<ISOAbbreviation>J Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.</ArticleTitle>
<Pagination><MedlinePgn>223-30</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.4049/jimmunol.1401985</ELocationID>
<Abstract><AbstractText>The mammalian target of rapamycin (mTOR) senses and incorporates different environmental cues via the two signaling complexes mTOR complex 1 (mTORC1) and mTORC2. As a result, mTOR controls cell growth and survival, and also shapes different effector functions of the cells including immune cells such as T cells. We demonstrate in this article that invariant NKT (iNKT) cell development is controlled by mTORC2 in a cell-intrinsic manner. In mice deficient in mTORC2 signaling because of the conditional deletion of the Rictor gene, iNKT cell numbers were reduced in the thymus and periphery. This is caused by decreased proliferation of stage 1 iNKT cells and poor development through subsequent stages. Functionally, iNKT cells devoid of mTORC2 signaling showed reduced number of IL-4-expressing cells, which correlated with a decrease in the transcription factor GATA-3-expressing cells. However, promyelocytic leukemia zinc-finger (PLZF), a critical transcription factor for iNKT cell development, is expressed at a similar level in mTORC2-deficient iNKT cells compared with that in the wild type iNKT cells. Furthermore, cellular localization of PLZF was not altered in the absence of mTOR2 signaling. Thus, our study reveals the PLZF-independent mechanisms of the development and function of iNKT cells regulated by mTORC2. </AbstractText>
<CopyrightInformation>Copyright © 2014 by The American Association of Immunologists, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Prevot</LastName>
<ForeName>Nicolas</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pyaram</LastName>
<ForeName>Kalyani</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bischoff</LastName>
<ForeName>Evan</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sen</LastName>
<ForeName>Jyoti Misra</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Powell</LastName>
<ForeName>Jonathan D</ForeName>
<Initials>JD</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Cheong-Hee</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109; heechang@umich.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI073677</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI073677</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI077610</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI077610</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R56 AI073677</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>11</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Immunol</MedlineTA>
<NlmUniqueID>2985117R</NlmUniqueID>
<ISSNLinking>0022-1767</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050990">GATA3 Transcription Factor</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C494748">Gata3 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020381">Interleukin-17</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051741">Kruppel-Like Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000075722">Promyelocytic Leukemia Zinc Finger Protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000076226">Rapamycin-Insensitive Companion of mTOR Protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C513267">Zbtb16 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C525637">rictor protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>207137-56-2</RegistryNumber>
<NameOfSubstance UI="D015847">Interleukin-4</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>82115-62-6</RegistryNumber>
<NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076225">Mechanistic Target of Rapamycin Complex 2</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050990" MajorTopicYN="N">GATA3 Transcription Factor</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020381" MajorTopicYN="N">Interleukin-17</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015847" MajorTopicYN="N">Interleukin-4</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051741" MajorTopicYN="N">Kruppel-Like Transcription Factors</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076225" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046912" MajorTopicYN="N">Multiprotein Complexes</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055611" MajorTopicYN="N">Natural Killer T-Cells</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000075722" MajorTopicYN="N">Promyelocytic Leukemia Zinc Finger Protein</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076226" MajorTopicYN="N">Rapamycin-Insensitive Companion of mTOR Protein</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>11</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>11</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>2</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25404366</ArticleId>
<ArticleId IdType="pii">jimmunol.1401985</ArticleId>
<ArticleId IdType="doi">10.4049/jimmunol.1401985</ArticleId>
<ArticleId IdType="pmc">PMC4315517</ArticleId>
<ArticleId IdType="mid">NIHMS638094</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Exp Med. 2002 Apr 1;195(7):835-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11927628</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Immunol. 2007;25:297-336</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17150027</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2003 Oct 6;198(7):1069-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14530376</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int Immunol. 2003 Dec;15(12):1485-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14645157</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2007 Apr 15;109(8):3316-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17170126</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2008 Apr 15;180(8):5448-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18390727</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2008 Jul 15;181(2):907-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18606642</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2008 Sep;9(9):1055-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18660811</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2008 Sep 19;29(3):391-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18703361</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2009 Jun 19;30(6):832-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19538929</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunology. 2009 Aug;127(4):459-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19604300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2010 Mar;11(3):197-206</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20139988</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2010 Jun 15;184(12):6746-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20495068</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2010 Jun 25;32(6):743-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20620941</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2010 Nov 15;185(10):5973-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20944007</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2011 Apr;12(4):295-303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21358638</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2011 Apr 22;34(4):541-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21511183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2011 Sep;12(9):888-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21765414</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Immunol. 2012;30:39-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22136167</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2012 Apr 9;209(4):713-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22473959</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2012 Apr 15;188(8):3859-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22492686</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2012 May;12(5):325-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22517423</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2012 Sep;249(1):43-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22889214</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2013 Nov;14(11):1146-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24097110</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):E776-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24516149</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2014 Mar 15;192(6):2643-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24532578</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2014 Apr;124(4):1685-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24614103</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2002 Apr 19;296(5567):553-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11968185</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2004 Nov;6(11):1122-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15467718</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2005 Aug 15;202(4):485-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16087715</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2014 Aug 15;193(4):1759-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25015820</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Michigan</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Michigan"><name sortKey="Prevot, Nicolas" sort="Prevot, Nicolas" uniqKey="Prevot N" first="Nicolas" last="Prevot">Nicolas Prevot</name>
</region>
<name sortKey="Bischoff, Evan" sort="Bischoff, Evan" uniqKey="Bischoff E" first="Evan" last="Bischoff">Evan Bischoff</name>
<name sortKey="Chang, Cheong Hee" sort="Chang, Cheong Hee" uniqKey="Chang C" first="Cheong-Hee" last="Chang">Cheong-Hee Chang</name>
<name sortKey="Powell, Jonathan D" sort="Powell, Jonathan D" uniqKey="Powell J" first="Jonathan D" last="Powell">Jonathan D. Powell</name>
<name sortKey="Pyaram, Kalyani" sort="Pyaram, Kalyani" uniqKey="Pyaram K" first="Kalyani" last="Pyaram">Kalyani Pyaram</name>
<name sortKey="Sen, Jyoti Misra" sort="Sen, Jyoti Misra" uniqKey="Sen J" first="Jyoti Misra" last="Sen">Jyoti Misra Sen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C69 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C69 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25404366
   |texte=   Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25404366" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.

Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki